You need to add it to your ~/.profile
or ~/.bashrc
file.
export PATH=$PATH:/path/to/dir
Depending on what you're doing, you also may want to symlink to binaries:
cd /usr/bin
sudo ln -s /path/to/binary binary-name
Note that this will not automatically update your path for the remainder of the session. To do this, you should run:
source ~/.profile
or
source ~/.bashrc