update `表名` set 字段名 =replace(字段名, '查找的内容','更改的内容') where 字段名 like '%查找的内容%';
update shangpin set click_url=replace(click_url,'21508360','1111111111') where click_url like '%21508360%';
http://www.cnblogs.com/heyubingfeng/archive/2013/03/13/2957872.html